Buffalo Bills
AFC · East · Division champion
13–4
WK Date Opponent Result Record
W1 Sun, Sep 8 Sep 8 CBS vs 
ARI
ARI W 34–28
(1-0)W2 Fri, Sep 13 Sep 13 Prime Video @ 
MIA
MIA W 31–10
(2-0)W3 Mon, Sep 23 Sep 23 ESPN vs 
JAX
JAX W 47–10
(3-0)W4 Mon, Sep 30 Sep 30 NBC @ 
BAL
BAL L 10–35
(3-1)W5 Sun, Oct 6 Oct 6 CBS @ 
HOU
HOU L 20–23
(3-2)W6 Tue, Oct 15 Oct 15 ESPN @ 
NYJ
NYJ W 23–20
(4-2)W7 Sun, Oct 20 Oct 20 CBS vs 
TEN
TEN W 34–10
(5-2)W8 Sun, Oct 27 Oct 27 FOX @ 
SEA
SEA W 31–10
(6-2)W9 Sun, Nov 3 Nov 3 CBS vs MIA
MIA W 30–27
(7-2)W10 Sun, Nov 10 Nov 10 CBS @ 
IND
IND W 30–20
(8-2)W11 Sun, Nov 17 Nov 17 CBS vs 
KC
KC W 30–21
(9-2)W12 BYE week
W13 Mon, Dec 2 Dec 2 NBC vs 
SF
SF W 35–10
(10-2)W14 Sun, Dec 8 Dec 8 FOX @ 
LAR
LAR L 42–44
(10-3)W15 Sun, Dec 15 Dec 15 CBS @ 
DET
DET W 48–42
(11-3)W16 Sun, Dec 22 Dec 22 CBS vs 
NE
NE W 24–21
(12-3)W17 Sun, Dec 29 Dec 29 CBS vs NYJ
NYJ W 40–14
(13-3)W18 Sun, Jan 5 Jan 5 CBS @ NE
NE L 16–23
(13-4)