San Francisco 49ers
NFC · West · First-round bye
12–5
WK Date Opponent Result Record
W1 Sun, Sep 10 Sep 10 FOX @ 
PIT
PIT W 30–7
(1-0)W2 Sun, Sep 17 Sep 17 FOX @ 
LAR
LAR W 30–23
(2-0)W3 Fri, Sep 22 Sep 22 Prime Video vs 
NYG
NYG W 30–12
(3-0)W4 Sun, Oct 1 Oct 1 FOX vs 
ARI
ARI W 35–16
(4-0)W5 Mon, Oct 9 Oct 9 NBC vs 
DAL
DAL W 42–10
(5-0)W6 Sun, Oct 15 Oct 15 FOX @ 
CLE
CLE L 17–19
(5-1)W7 Tue, Oct 24 Oct 24 ABC @ 
MIN
MIN L 17–22
(5-2)W8 Sun, Oct 29 Oct 29 CBS vs 
CIN
CIN L 17–31
(5-3)W9 BYE week
W10 Sun, Nov 12 Nov 12 FOX @ 
JAX
JAX W 34–3
(6-3)W11 Sun, Nov 19 Nov 19 FOX vs 
TB
TB W 27–14
(7-3)W12 Fri, Nov 24 Nov 24 NBC @ 
SEA
SEA W 31–13
(8-3)W13 Sun, Dec 3 Dec 3 FOX @ 
PHI
PHI W 42–19
(9-3)W14 Sun, Dec 10 Dec 10 FOX vs SEA
SEA W 28–16
(10-3)W15 Sun, Dec 17 Dec 17 CBS @ ARI
ARI W 45–29
(11-3)W16 Tue, Dec 26 Dec 26 ABC vs 
BAL
BAL L 19–33
(11-4)W17 Sun, Dec 31 Dec 31 FOX @ 
WSH
WSH W 27–10
(12-4)W18 Sun, Jan 7 Jan 7 FOX vs LAR
LAR L 20–21
(12-5)