San Francisco 49ers
NFC · West · Playoff berth clinched
12–5
WK Date Opponent Result Record
W1 Sun, Sep 7 Sep 7 FOX @ 
SEA
SEA W 17–13
(1-0)W2 Sun, Sep 14 Sep 14 FOX @ 
NO
NO W 26–21
(2-0)W3 Sun, Sep 21 Sep 21 FOX vs 
ARI
ARI W 16–15
(3-0)W4 Sun, Sep 28 Sep 28 FOX vs 
JAX
JAX L 21–26
(3-1)W5 Fri, Oct 3 Oct 3 Prime Video @ 
LAR
LAR W 26–23
(4-1)W6 Sun, Oct 12 Oct 12 CBS @ 
TB
TB L 19–30
(4-2)W7 Mon, Oct 20 Oct 20 NBC vs 
ATL
ATL W 20–10
(5-2)W8 Sun, Oct 26 Oct 26 FOX @ 
HOU
HOU L 15–26
(5-3)W9 Sun, Nov 2 Nov 2 CBS @ 
NYG
NYG W 34–24
(6-3)W10 Sun, Nov 9 Nov 9 FOX vs LAR
LAR L 26–42
(6-4)W11 Sun, Nov 16 Nov 16 FOX @ ARI
ARI W 41–22
(7-4)W12 Tue, Nov 25 Nov 25 ESPN vs 
CAR
CAR W 20–9
(8-4)W13 Sun, Nov 30 Nov 30 CBS @ 
CLE
CLE W 26–8
(9-4)W14 BYE week
W15 Sun, Dec 14 Dec 14 FOX vs 
TEN
TEN W 37–24
(10-4)W16 Tue, Dec 23 Dec 23 ESPN @ 
IND
IND W 48–27
(11-4)W17 Mon, Dec 29 Dec 29 NBC vs 
CHI
CHI W 42–38
(12-4)W18 Sun, Jan 4 Jan 4 ABC vs SEA
SEA L 3–13
(12-5)